Protein C and S Deficiency, Thrombophilia, and Hypofibrinolysis: Pathophysiologic Causes of Legg-Perthes Disease

Evolution in diagnosis and treatment of Legg-Calve-Perthes disease

Legg-Calvé-Perthes disease (LCPD) is an idiopathic osteonecrosis of the femoral head with variable complications and resultant deformity of the femoral head and osteoarthritis. Suggested risk factors are acetabular retroversion, obesity, latitude, hyperactivity, and coagulopathy. The most commonly applied classification is based on radiolucency in the lateral pillar of the femoral head, which i...

Heritable thrombophilia and hypofibrinolysis. Possible causes of retinal vein occlusion.

OBJECTIVE To determine whether heritable thrombophilia and hypofibrinolysis were risk factors for retinal vein occlusion. DESIGN Measures of thrombophilia (increased likelihood of thrombus formation) included anticardiolipin antibodies (IgG and IgM), the lupus anticoagulant (including dilute Russell viper venom clotting time), antigenic proteins C and S, and homocysteine. Polymerase chain rea...

Legg–Calvé–Perthes Disease — Symptoms and Classification

Legg–Calvé–Perthes Disease — Symptoms and Classification

Legg–Calvé–Perthes Disease — Symptoms and Classification